SRGAP1 controls small Rho GTPases to regulate podocyte foot process maintenance

ABSTRACT: Podocyte foot process effacement and proteinuria is a common and uniform consequence of glomerular injury. Previously it has been shown that small Rho GTPases (e.g. RAC1) are drivers of podocyte foot process effacement in glomerular diseases such as focal segmental glomerulosclerosis (FSGS). However, a comprehensive understanding of the regulatory networks of small Rho GTPases will be a prerequisite for precisely targeted therapeutic interventions.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Oliver Schilling  

PROVIDER: MSV000085853 | MassIVE | Thu Jul 30 13:38:00 BST 2020

SECONDARY ACCESSION(S): PXD020649

REPOSITORIES: MassIVE