Proteomics

Dataset Information

0

Dysregulation of the de novo proteome accompanies pathology progression in the APP/PS1 mouse model


ABSTRACT: We hypothesize that alterations in the de novo proteome drive early metabolic alterations in the hippocampus that persist throughout AD progression. Using a combinatorial amino acid tagging approach to selectively label newly synthesized proteins, we found that the de novo proteome is disturbed in APP/PS1 mice prior to pathology development, affecting the synthesis of multiple components of the synaptic, lysosomal and mitochondrial pathways.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Thomas A. Neubert  

PROVIDER: MSV000085962 | MassIVE | Mon Aug 17 08:57:00 BST 2020

REPOSITORIES: MassIVE

Similar Datasets

2019-12-21 | GSE124242 | GEO
2015-03-03 | E-GEOD-59124 | biostudies-arrayexpress
2015-03-03 | GSE59124 | GEO
2020-02-28 | GSE139062 | GEO
2020-02-28 | GSE139060 | GEO
2023-10-24 | PXD043494 | Pride
2023-10-24 | PXD043498 | Pride
2020-10-08 | PXD019243 | Pride
2010-09-01 | E-GEOD-23572 | biostudies-arrayexpress
2016-10-14 | GSE87802 | GEO