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Metaproteome of preterm infant gut microbiome

ABSTRACT: 91 preterm infant gut metaproteomes measured in technical duplicate using an eleven salt pulse 2D-LC-MS/MS method. Samples represent 17 preterm infants over the first several weeks of life, of which 6 preterm infants eventually developed necrotizing enterocolitis.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Microbiome

SUBMITTER: Robert L. Hettich

PROVIDER: MSV000086096 | MassIVE |

REPOSITORIES: MassIVE

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Hospitalized Premature Infants Are Colonized by Related Bacterial Strains with Distinct Proteomic Profiles.

Brown Christopher T CT Xiong Weili W Olm Matthew R MR Thomas Brian C BC Baker Robyn R Firek Brian B Morowitz Michael J MJ Hettich Robert L RL Banfield Jillian F JF

mBio 20180410 2

During the first weeks of life, microbial colonization of the gut impacts human immune system maturation and other developmental processes. In premature infants, aberrant colonization has been implicated in the onset of necrotizing enterocolitis (NEC), a life-threatening intestinal disease. To study the premature infant gut colonization process, genome-resolved metagenomics was conducted on 343 fecal samples collected during the first 3 months of life from 35 premature infants housed in a neonat ...[more]

PMID: 29636439

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