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Human blood plasma circadian lipidome misalignment due to night shift simulation

ABSTRACT: Blood plasma was collected from a total of 14 subjects participating in a between-groups, in-laboratory study. Healthy volunteers (ages 22-34, BMI average 25.7) were assigned to a 3 day simulated night-shift schedule (6 male, 1 female) or a simulated day-shift (i.e., control, 4 male, 3 female) schedule. For each group, this was followed by a 24-h constant routine protocol, during which blood was drawn at 3-h intervals to measure plasma lipid profiles using LC-MS/MS.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Thomas Metz

PROVIDER: MSV000086152 | MassIVE |

REPOSITORIES: MassIVE

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Simulated Night-Shift Schedule Disrupts the Plasma Lipidome and Reveals Early Markers of Cardiovascular Disease Risk.

Kyle Jennifer E JE Bramer Lisa M LM Claborne Daniel D Stratton Kelly G KG Bloodsworth Kent J KJ Teeguarden Justin G JG Gaddameedhi Shobhan S Metz Thomas O TO Van Dongen Hans P A HPA

Nature and science of sleep 20220521

<h4>Introduction</h4>The circadian system coordinates daily rhythms in lipid metabolism, storage and utilization. Disruptions of internal circadian rhythms due to altered sleep/wake schedules, such as in night-shift work, have been implicated in increased risk of cardiovascular disease and metabolic disorders. To determine the impact of a night-shift schedule on the human blood plasma lipidome, an in-laboratory simulated shift work study was conducted.<h4>Methods</h4>Fourteen healthy young adult ...[more]

PMID: 35645584

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