A Fbxo48 inhibitor prevents pAMPKa degradation and ameliorates insulin resistance

ABSTRACT: Beas-2b cells treated with vehicle or BC1618 compound, which targets the ubiquitin E3 ligase for targeted degradation of pAMPKa protein. Cell lysate was subjected to mass spectrometry for phosphoproteomics to uncover alterations in the phosphoproteome.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Bill Chen  

PROVIDER: MSV000086334 | MassIVE | Tue Oct 20 11:15:00 BST 2020

REPOSITORIES: MassIVE