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Proteomic and Genomic Methylation Signatures of Idiopathic Subglottic Stenosis

ABSTRACT: LC-MS/MS data obtained from subglottic biopsies collected from 12 individuals with idiopathic subglottic stenosis, as well as 3 age-, sex-, and race/ethnicity-matched controls. All tissue donors were women of White race and non-Latino or Hispanic ethnicity. Sample preparation, mass spectrometry, and data analysis details are available in the published article.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Nathan Welham

PROVIDER: MSV000086498 | MassIVE | Sat Nov 21 15:09:00 GMT 2020

REPOSITORIES: MassIVE

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Proteomic and Genomic Methylation Signatures of Idiopathic Subglottic Stenosis.

Schoeff Stephen S SS Shi Xudong X Young William G WG Whited Chad W CW Soni Resha S RS Liu Peng P Ong Irene M IM Dailey Seth H SH Welham Nathan V NV

The Laryngoscope 20200703 2

<h4>Objective</h4>Idiopathic subglottic stenosis (iSGS) is a chronic inflammatory condition that causes dyspnea and affects middle-aged women of White race and non-Latino or Hispanic ethnicity. To better characterize its phenotype and pathogenesis, we assessed the proteomic and genomic methylation signatures of subglottic tissue collected from iSGS patients compared to controls.<h4>Study design</h4>Molecular analysis of clinical biospecimens.<h4>Methods</h4>We collected subglottic tissue biopsie ...[more]

PMID: 32619300

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