Quantitative proteomics identifies ML111 as a cell-cycle inhibitor

ABSTRACT: We used quantitative mass spectrometry to analyze the effect of ML111 on the whole proteome of SK-N-MC cells. Results: ML111 treatment results in the accumulation of APC/C substrates suggesting that ML111 disrupts the cell cycle at or before the mitotic spindle assembly checkpoint.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Mark Leid  

PROVIDER: MSV000086599 | MassIVE | Tue Dec 15 13:03:00 GMT 2020

SECONDARY ACCESSION(S): PXD023150

REPOSITORIES: MassIVE