Proteomics

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Lambert_TBX2_characterization_HEK293_P82_VS18

ABSTRACT: This set of submissions contains the mass spectrometry files by Jean-Philippe Lambert et al. that describes the functional characterization of TBX2. AP-MS and BioID experiments were performed from Flp-In T-REx HEK293 cells and MS files were acquired on 5600 TripleTOF mass spectrometers. Different MassIVE submissions corresponding to SAINT Task Results (see list below) have been made; this README file pertains to all submissions. For questions, please contact Jean-Philippe Lambert (Jean-Philippe.Lambert@crchudequebec.ulaval.ca).

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Jean-Philippe Lambert  

PROVIDER: MSV000086613 | MassIVE | Thu Dec 17 11:03:00 GMT 2020

REPOSITORIES: MassIVE

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Publications

Senescence shapes embryonic development, plays a key role in aging, and is a critical barrier to cancer initiation, yet how senescence is regulated remains incompletely understood. TBX2 is an antisenescence T-box family transcription repressor implicated in embryonic development and cancer. However, the repertoire of TBX2 target genes, its cooperating partners, and how TBX2 promotes proliferation and senescence bypass are poorly understood. Here, using melanoma as a model, we show that TBX2 lies  ...[more]

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