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Modular biomaterials vaccine technology protects against multiple pathogens and septic shock

ABSTRACT: We have developed a composite infection vaccine technology (ciVAX) assembled from approved products for rapid response to pandemics and biothreat agents. ciVAX consists of an injectable biomaterial scaffold containing factors that recruit, reprogram and release dendritic cells (DC) in vivo. For bacterial infections, ciVAX contains Fc-Mannose-Binding Lectin (FcMBL) microbeads with captured PAMPs fractions from inactivated bacterial cell-wall lysates. ciVAX vaccination generates potent humoral and T cell responses to bacterial antigens, and ciVAX protects mice and pigs against lethal E coli challenge in sepsis and septic shock models

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Staphylococcus Aureus (ncbitaxon:1280) Escherichia Coli (ncbitaxon:562)

SUBMITTER: David J Mooney

PROVIDER: MSV000086751 | MassIVE | Fri Jan 22 14:11:00 GMT 2021

SECONDARY ACCESSION(S): PXD023763

REPOSITORIES: MassIVE

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