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Cardiolipin remodeling enables protein crowding in the inner mitochondrial membrane

ABSTRACT: Mitochondrial cristae are more crowded with proteins than other cellular membranes. However, protein crowding stresses the bilayer organization of lipids, which challenges membrane stability. We tested the hypothesis that the high concentration of proteins drives the tafazzin-catalyzed remodeling of fatty acids in cardiolipin (CL) to reduce stress on the lipid bilayer

INSTRUMENT(S): Q Exactive HF, Q Exactive

ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227) Saccharomyces Cerevisiae (ncbitaxon:4932) Mus Musculus (ncbitaxon:10090)

SUBMITTER: Dr. Thomas A. Neubert Dr. Michael Schlame

PROVIDER: MSV000087602 | MassIVE | Thu Jun 10 08:43:00 BST 2021

SECONDARY ACCESSION(S): PXD026620

REPOSITORIES: MassIVE

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