Dataset Information
Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors
Ontology highlight
ABSTRACT:
INSTRUMENT(S): 6550 iFunnel Q-TOF LC/MS
ORGANISM(S): Mus Musculus (ncbitaxon:10090)
SUBMITTER: 
Michael Scharl
PROVIDER: MSV000087624 | MassIVE | Tue Jun 15 06:29:00 BST 2021
REPOSITORIES: MassIVE
Publications
Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors.
Cell host & microbe 20210827 10
Despite overall success, T cell checkpoint inhibitors for cancer treatment are still only efficient in a minority of patients. Recently, intestinal microbiota was found to critically modulate anti-cancer immunity and therapy response. Here, we identify Clostridiales members of the gut microbiota associated with a lower tumor burden in mouse models of colorectal cancer (CRC). Interestingly, these commensal species are also significantly reduced in CRC patients compared with healthy controls. Oral ...[more]
