Discovery of novel macrolides: Epemicins A and B

ABSTRACT: Identification of two novel 30-membered glycosylated macrolides, epemicins A and B from the rare Kutzneria sp. CA-103260 with formulas C70H122N2O27 and C76H132N2O32. We also provide data on the successful heterologous expression of epemicin A in S. albus J1074 and on the abolishment of the production of the compounds via the generation of a knockout strain. The whole genome sequence of Kutzneria sp. CA-103260 available at: https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=2802641&lvl=3&lin=f&keep=1&srchmode=1&unlock The published data are available at: https://pubs.acs.org/doi/full/10.1021/acschembio.1c00318

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Kutzneria Sp. Ca-103260

SUBMITTER: Karl Tilmann Weber  

PROVIDER: MSV000087858 | MassIVE | Tue Jul 20 14:06:00 BST 2021

REPOSITORIES: MassIVE