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Temporal Proteomics During Neurogenesis Reveals Large-scale Proteome and Organelle Remodeling via Selective Autophagy

ABSTRACT: Raw mass spectrometry data associated with the following paper: Temporal Proteomics During Neurogenesis Reveals Large-scale Proteome and Organelle Remodeling via Selective Autophagy. DOI:10.1016/j.molcel.2021.10.001 Related to Figure1D: AO3335-AO3345 Related to Figure4B: Day0 (AO3379-3390); Day4 (AO3397-3408); Day12 (AO3415-3426)

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: J. Wade Harper Alban Ordureau

PROVIDER: MSV000087961 | MassIVE | Mon Aug 09 11:56:00 BST 2021

REPOSITORIES: MassIVE

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Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy.

Ordureau Alban A Kraus Felix F Zhang Jiuchun J An Heeseon H Park Sookhee S Ahfeldt Tim T Paulo Joao A JA Harper J Wade JW

Molecular cell 20211025 24

Cell state changes are associated with proteome remodeling to serve newly emergent cell functions. Here, we show that NGN2-driven conversion of human embryonic stem cells to induced neurons (iNeurons) is associated with increased PINK1-independent mitophagic flux that is temporally correlated with metabolic reprogramming to support oxidative phosphorylation. Global multiplex proteomics during neurogenesis revealed large-scale remodeling of functional modules linked with pluripotency, mitochondri ...[more]

PMID: 34699746

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