Dataset Information
OGT controls mammalian cell viability by regulating the proteasome/mTOR/mitochondrial axis
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF-X
ORGANISM(S): Mus Musculus (ncbitaxon:10090)
SUBMITTER: 
Anjana Rao
PROVIDER: MSV000088393 | MassIVE | Tue Nov 16 10:21:00 GMT 2021
REPOSITORIES: MassIVE
Publications
OGT controls mammalian cell viability by regulating the proteasome/mTOR/ mitochondrial axis.
Proceedings of the National Academy of Sciences of the United States of America 20230110 3
<i>O</i>-GlcNAc transferase (OGT) modifies serine and threonine residues on nuclear and cytosolic proteins with <i>O</i>-linked N-acetylglucosamine (GlcNAc). OGT is essential for mammalian cell viability, but the underlying mechanisms are still enigmatic. We performed a genome-wide CRISPR-Cas9 screen in mouse embryonic stem cells (mESCs) to identify candidates whose depletion rescued the block in cell proliferation induced by OGT deficiency. We show that the block in cell proliferation in OGT-de ...[more]
