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Mapping the Proteoform Landscape of Five Human Tissues

ABSTRACT: Untargeted top-down LC-MS and CZE-MS of five human tissues (kidney, lung, spleen, small intestine, and heart)

INSTRUMENT(S): Orbitrap Eclipse, Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Neil Kelleher

PROVIDER: MSV000088565 | MassIVE | Tue Dec 14 11:05:00 GMT 2021

REPOSITORIES: MassIVE

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Mapping the Proteoform Landscape of Five Human Tissues.

Drown Bryon S BS Jooß Kevin K Melani Rafael D RD Lloyd-Jones Cameron C Camarillo Jeannie M JM Kelleher Neil L NL

Journal of proteome research 20220412 5

A functional understanding of the human body requires structure-function studies of proteins at scale. The chemical structure of proteins is controlled at the transcriptional, translational, and post-translational levels, creating a variety of products with modulated functions within the cell. The term "proteoform" encapsulates this complexity at the level of chemical composition. Comprehensive mapping of the proteoform landscape in human tissues necessitates analytical techniques with increased ...[more]

PMID: 35413190

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