Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: Laurent GENESTIER
PROVIDER: MSV000089045 | MassIVE | Thu Mar 10 23:59:00 GMT 2022
REPOSITORIES: MassIVE
Delage Lorric L Lambert Mireille M Bardel Émilie É Kundlacz Cindy C Chartoire Dimitri D Conchon Axel A Peugnet Anne-Laure AL Gorka Lucas L Auberger Patrick P Jacquel Arnaud A Soussain Carole C Destaing Olivier O Delecluse Henri-Jacques HJ Delecluse Susanne S Merabet Samir S Traverse-Glehen Alexandra A Salles Gilles G Bachy Emmanuel E Billaud Marc M Ghesquières Hervé H Genestier Laurent L Rouault Jean-Pierre JP Sujobert Pierre P
Blood 20230301 10
Understanding the functional role of mutated genes in cancer is required to translate the findings of cancer genomics into therapeutic improvement. BTG1 is recurrently mutated in the MCD/C5 subtype of diffuse large B-cell lymphoma (DLBCL), which is associated with extranodal dissemination. Here, we provide evidence that Btg1 knock out accelerates the development of a lethal lymphoproliferative disease driven by Bcl2 overexpression. Furthermore, we show that the scaffolding protein BCAR1 is a BTG ...[more]