Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

An embeddable molecular code for Lewis X modification through interaction with fucosyltansferase 9

ABSTRACT: MS results support Lewis X modification through interaction with fucosyltransferase 9

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Kay-Hooi Khoo

PROVIDER: MSV000089274 | MassIVE | Mon Apr 18 17:45:00 BST 2022

REPOSITORIES: MassIVE

ACCESS DATA

Json Xml

Similar Datasets

A20 regulates canonical wnt-signaling through an interaction with RIPK4

Project description:A20 regulates canonical wnt-signaling through an interaction with RIPK4

| PRJNA435878 | ENA

Bacterial Intestinal Gut Modification Around Cancer Surgery (BIG MACS) Diet

Project description:The long-term study objective is to develop optimized nutritional therapies for surgery and test them in clinical practice. This pilot study will test a microbiome-optimization diet in colorectal cancer surgery patients. The study hypothesizes that the Bacterial Intestinal Gut Modification Around Cancer Surgery (BIG MACS) Diet will provide participants with increased microbiota accessible carbohydrates (MACs) to support the microbiome and improve outcomes.

| 2972 | ecrin-mdr-crc

KRAS K104 modification affects KRASG12D-GEF interaction and mediated cell growth and motility

Project description:KRAS K104 modification affects KRASG12D-GEF interaction and mediated cell growth and motility

| PRJNA664398 | ENA

tRNA Modification Identification and Quantification through High Throughput Sequencing

Project description:We report the identification and quantification of Watson-Crick modifications in tRNA and rRNA through the use of high throughput sequencing. We apply the recently published DM-tRNA-Seq method to generate demethylase treated and untreated 293T samples, and using computational methods we are able to flag sites using a modification index. This index allows us to generate site-resolved information about modification that we can use to identify and quantify Watson-Crick face modifications in tRNA and rRNA. With the demethylase treated samples, we are able to validate numerous nucleotide modifications from demethylase substrates, and the absence of demethylase action also serves to aid in identification. We find numerous novel modification sites in tRNA as well as striking comparisons between tissues cultures lines. Our study reports a comprehensive analysis of the tRNA modification landscape by identifying sites of modification as well as quantifying modification levels.

2017-02-10 | GSE76434 | GEO

An embeddable molecular code for Lewis X modification through interaction with fucosyltransferase 9.

Project description: Not available

| S-EPMC9279290 | biostudies-literature

Regulation of T helper cell differentiation by the interplay between histone modification and chromatin interaction

Project description:The development and function of the immune system are controlled by temporospatial gene expression programs, which are regulated by cis-regulatory elements, chromatin structure, and trans-acting factors. In this study, we cataloged the dynamic histone modifications and chromatin interactions at regulatory regions during T helper (Th) cell differentiation. Our data revealed that the H3K4me1 landscape established by MLL4 in naive CD4+ T cells is critical for restructuring the regulatory interaction network and orchestrating gene expression during the early phase of Th differentiation. GATA3 plays a crucial role in further configuring H3K4me1 modification and the chromatin interaction network during Th2 differentiation. Furthermore, we demonstrated that HSS3-anchored chromatin loops function to restrict the activity of the Th2 locus control region (LCR), thus coordinating the expression of Th2 cytokines. Our results provide insights into the mechanisms of how the interplay between histone modifications, chromatin looping, and trans-acting factors contributes to the differentiation of Th cells.

2024-03-01 | GSE237916 | GEO

Cancer Malignancy Is Correlated with Upregulation of PCYT2-Mediated Glycerol Phosphate Modification of alpha-Dystroglycan

Project description:LC-MS and MS/MS results support glycerol phosphate modification of alpha-dystroglycan

2022-06-12 | MSV000089635 | MassIVE

Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer

Project description:Quantitative and qualitative changes in mRNA translation occur in tumor cells and support cancer progression and metastasis. Post-transcriptional nucleoside modifications of transfer RNAs (tRNAs) at the wobble U34 base are highly conserved and contribute to translation fidelity. Here, we show that ELP3 and CTU1/2, partner enzymes in U34 mcm5s2-tRNA modification, are upregulated in human breast cancers and sustain metastasis. Elp3 genetic ablation strongly impaired invasion and metastasis formation in the PyMT model of invasive breast cancer. Mechanistically, ELP3 and CTU1/2 support cellular invasion through the translation of the oncoprotein DEK. As a result, DEK promotes the IRES-dependent translation of the pro-invasive transcription factor LEF1. Consistently, a DEK mutant, whose codon composition is independent of U34 mcm5s2-tRNA modification, escapes the ELP3- and CTU1-dependent regulation and restores the IRES-dependent LEF1 expression. Our results demonstrate the key role of U34 tRNA modification to support specific translation during breast cancer progression and highlight a functional link between tRNA modification- and IRES-dependent translation during tumor cell invasion and metastasis.analysis of transcriptomic changes due to Elp3genetic deletion in cells extracted from PyMT mammary tumors.

2016-09-29 | GSE85810 | GEO

m6A modification involves in enriched environment-induced neurogenesis and cognition enhancement

Project description:Our results suggest that different environment induces differential m6A mRNA modification, and add novel layer of the interaction between environment and epigenetics during the postnatal neuronal development.

2022-06-22 | GSE197754 | GEO

MeCP2 regulates gene expression through direct interaction with H3K27me3 [ChIP_human: HCT116_vs_DKO1]

Project description:MeCP2 regulates gene expression through direct interaction with H3K27me3 [ChIP_human: HCT116_vs_DKO1]

| PRJNA561339 | ENA