A non-canonical vitamin K cycle is a potent ferroptosis suppressor
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Mus Musculus (ncbitaxon:10090)
SUBMITTER: 
Maria Fedorova
PROVIDER: MSV000089489 | MassIVE | Thu May 19 04:58:00 BST 2022
REPOSITORIES: MassIVE
Publications
A non-canonical vitamin K cycle is a potent ferroptosis suppressor.
Mishima Eikan E Ito Junya J Wu Zijun Z Nakamura Toshitaka T Wahida Adam A Doll Sebastian S Tonnus Wulf W Nepachalovich Palina P Eggenhofer Elke E Aldrovandi Maceler M Henkelmann Bernhard B Yamada Ken-Ichi KI Wanninger Jonas J Zilka Omkar O Sato Emiko E Feederle Regina R Hass Daniela D Maida Adriano A Mourão André Santos Dias ASD Linkermann Andreas A Geissler Edward K EK Nakagawa Kiyotaka K Abe Takaaki T Fedorova Maria M Proneth Bettina B Pratt Derek A DA Conrad Marcus M
Nature 20220803 7924
Ferroptosis, a non-apoptotic form of cell death marked by iron-dependent lipid peroxidation<sup>1</sup>, has a key role in organ injury, degenerative disease and vulnerability of therapy-resistant cancers<sup>2</sup>. Although substantial progress has been made in understanding the molecular processes relevant to ferroptosis, additional cell-extrinsic and cell-intrinsic processes that determine cell sensitivity toward ferroptosis remain unknown. Here we show that the fully reduced forms of vitam ...[more]
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