Comparative proteomics of Adult Paragominus kellikotti excretion/secretion products released in vitro or present in the lung cyst nodule

ABSTRACT: The aims of this study were to study ESPs to improve understanding of parasite-host interactions and to support the discovery of novel diagnostic or therapeutic targets. We used tandem mass-spectrometry to characterize the secretome of adult P. kellicotti flukes and to compare ESPs released during in vitro culture with parasite cyst fluid proteins (CFPs) which correspond to ESPs released by adult flukes in vivo. We also compared these results to the global proteome of soluble, somatic protein (SSP) extracts of whole adult flukes.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Paragominus Kellikotti

SUBMITTER: Peter U. Fischer  

PROVIDER: MSV000089589 | MassIVE | Thu Jun 02 16:05:00 BST 2022

SECONDARY ACCESSION(S): PXD034272

REPOSITORIES: MassIVE