Proteomics

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Tracheal aspirate proteome from hospitalized patients infected with SARS-CoV-2

ABSTRACT: Tracheal aspirate was collected from intubated patients with SARS-CoV-2 infections or for reasons not related to COVID-19 (controls). The proteins were extracted using the MPLEx method. Proteins were digested with trypsin and analyzed by LC-MS/MS on a Thermo Q Exactive HF-X. Data was searched with MaxQuant.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Geremy Clair  

PROVIDER: MSV000089614 | MassIVE | Mon Jun 06 15:17:00 BST 2022

REPOSITORIES: MassIVE

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Publications

Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes.

Zhang Yue Y   Bharathi Vanthana V   Dokoshi Tatsuya T   de Anda Jaime J   Ursery Lauryn Tumey LT   Kulkarni Nikhil N NN   Nakamura Yoshiyuki Y   Chen Jonathan J   Luo Elizabeth W C EWC   Wang Lamei L   Xu Hua H   Coady Alison A   Zurich Raymond R   Lee Michelle W MW   Matsui Tsutomu T   Lee HongKyu H   Chan Liana C LC   Schepmoes Athena A AA   Lipton Mary S MS   Zhao Rui R   Adkins Joshua N JN   Clair Geremy C GC   Thurlow Lance R LR   Schisler Jonathan C JC   Wolfgang Matthew C MC   Hagan Robert S RS   Yeaman Michael R MR   Weiss Thomas M TM   Chen Xinhua X   Li Melody M H MMH   Nizet Victor V   Antoniak Silvio S   Mackman Nigel N   Gallo Richard L RL   Wong Gerard C L GCL  

Proceedings of the National Academy of Sciences of the United States of America 20240202 6

It is unclear how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to the strong but ineffective inflammatory response that characterizes severe Coronavirus disease 2019 (COVID-19), with amplified immune activation in diverse cell types, including cells without angiotensin-converting enzyme 2 receptors necessary for infection. Proteolytic degradation of SARS-CoV-2 virions is a milestone in host viral clearance, but the impact of remnant viral peptide fragments from hi  ...[more]

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