Coordinated transcriptional and catabolic programs support iron dependent adaptation to RAS-MAPK pathway inhibition in pancreatic cancer

ABSTRACT: Proteomics analysis of purified lysosomes isolated from KP4 human pancreatic ductal adenocarcinoma cells grown in 2D treated with DMSO (CTRL) or Trametinib (Tram) for 48hrs in full growth media. Elutes were quantified for total protein and equal protein amounts were submitted for mass spectrometry. See Ravichandran et al Cancer Discovery 2022

INSTRUMENT(S): ThermoFisher Orbitrap Elite

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Rushika M. Perera  

PROVIDER: MSV000089676 | MassIVE | Thu Jun 16 19:43:00 BST 2022

REPOSITORIES: MassIVE