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Metaproteomic investigation on T1D children at the onset

ABSTRACT: Metaproteomic investigation to unveil human gut microbiota features possibly linked to the onset of type 1 diabetes

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Bacteria Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Stefano Levi Mortera

PROVIDER: MSV000089691 | MassIVE | Tue Jun 21 02:12:00 BST 2022

REPOSITORIES: MassIVE

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Functional and Taxonomic Traits of the Gut Microbiota in Type 1 Diabetes Children at the Onset: A Metaproteomic Study.

Levi Mortera Stefano S Marzano Valeria V Vernocchi Pamela P Matteoli Maria Cristina MC Guarrasi Valerio V Gardini Simone S Del Chierico Federica F Rapini Novella N Deodati Annalisa A Fierabracci Alessandra A Cianfarani Stefano S Putignani Lorenza L

International journal of molecular sciences 20221215 24

Type 1 diabetes (T1D) is a chronic autoimmune metabolic disorder with onset in pediatric/adolescent age, characterized by insufficient insulin production, due to a progressive destruction of pancreatic β-cells. Evidence on the correlation between the human gut microbiota (GM) composition and T1D insurgence has been recently reported. In particular, 16S rRNA-based metagenomics has been intensively employed in the last decade in a number of investigations focused on GM representation in relation t ...[more]

PMID: 36555624

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