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Omics score: 1000

Pseudomonas aeruginosa clinical isolates

ABSTRACT: 35 P. aeruginosa clinical strains were cultivated under standard conditions, characterized in terms of virulence and biofilm phenotype, and their metabolomes were investigated by untargeted liquid chromatography-mass spectrometry.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Pseudomonas Aeruginosa (ncbitaxon:287)

SUBMITTER: Mark Broenstrup

PROVIDER: MSV000089869 | MassIVE | Tue Jul 12 02:57:00 BST 2022

REPOSITORIES: MassIVE

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Untargeted LC-MS Metabolomics Differentiates Between Virulent and Avirulent Clinical Strains of Pseudomonas aeruginosa.

Depke Tobias T Thöming Janne Gesine JG Kordes Adrian A Häussler Susanne S Brönstrup Mark M

Biomolecules 20200713 7

Pseudomonas aeruginosa is a facultative pathogen that can cause, inter alia, acute or chronic pneumonia in predisposed individuals. The gram-negative bacterium displays considerable genomic and phenotypic diversity that is also shaped by small molecule secondary metabolites. The discrimination of virulence phenotypes is highly relevant to the diagnosis and prognosis of P. aeruginosa infections. In order to discover small molecule metabolites that distinguish different virulence phe ...[more]

PMID: 32668735

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