Proteomics

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Reverse N-terminomics of SARS-CoV-2 PLpro in A549

ABSTRACT: Subtiligase based N-terminomics (Abu N-terminal tagging) of two A549 cell lysate replicates incubated with SARS-CoV-2 PLpro.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Olivier Julien  

PROVIDER: MSV000090125 | MassIVE | Fri Aug 12 22:22:00 BST 2022

REPOSITORIES: MassIVE

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Identification of Human Host Substrates of the SARS-CoV-2 M<sup>pro</sup> and PL<sup>pro</sup> Using Subtiligase N-Terminomics.

Luo Shu Y SY   Moussa Eman W EW   Lopez-Orozco Joaquin J   Felix-Lopez Alberto A   Ishida Ray R   Fayad Nawell N   Gomez-Cardona Erik E   Wang Henry H   Wilson Joyce A JA   Kumar Anil A   Hobman Tom C TC   Julien Olivier O  

ACS infectious diseases 20230403 4

The recent emergence of SARS-CoV-2 in the human population has caused a global pandemic. The virus encodes two proteases, M<sup>pro</sup> and PL<sup>pro</sup>, that are thought to play key roles in the suppression of host protein synthesis and immune response evasion during infection. To identify the specific host cell substrates of these proteases, active recombinant SARS-CoV-2 M<sup>pro</sup> and PL<sup>pro</sup> were added to A549 and Jurkat human cell lysates, and subtiligase-mediated N-term  ...[more]

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