Proteomic analysis of Adnp mutant mice

ABSTRACT: We report age-differential synaptic plasticity deficits associated with cognitive inflexibility and CaMKIIa hyperactivity in Adnp-mutant mice. These mice show impaired and inflexible contextual learning and memory additional to social and anxiety-related deficits in adults long after a marked decrease in ADNP protein levels to ~10% of newborn levels in juveniles. In addition, Adnp-mutant adults show abnormally enhanced long-term potentiation in adults but not in juveniles. This accompanies CaMKIIa hyperactivity involving increased baseline autophosphorylation, as revealed by unbiased proteomic analyses.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Jin Young Kim  

PROVIDER: MSV000090257 | MassIVE |

SECONDARY ACCESSION(S): PXD036544

REPOSITORIES: MassIVE