Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Eclipse, Agilent 8890 GC-MS, Orbitrap Exploris 480
ORGANISM(S): Pseudomonas Putida Kt2440 (ncbitaxon:160488)
SUBMITTER:
Kristin Burnum-Johnson
PROVIDER: MSV000090294 | MassIVE |
REPOSITORIES: MassIVE

Metabolic engineering 20230215
Deciphering the mechanisms of bacterial fatty acid biosynthesis is crucial for both the engineering of bacterial hosts to produce fatty acid-derived molecules and the development of new antibiotics. However, gaps in our understanding of the initiation of fatty acid biosynthesis remain. Here, we demonstrate that the industrially relevant microbe Pseudomonas putida KT2440 contains three distinct pathways to initiate fatty acid biosynthesis. The first two routes employ conventional β-ketoacyl-ACP s ...[more]