Chen Minor et al 2023 Mass Spectrometry Data
Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: 
Balyn Zaro
PROVIDER: MSV000090434 | MassIVE |
REPOSITORIES: MassIVE
Publications
EMC chaperone-Ca<sub>V</sub> structure reveals an ion channel assembly intermediate.
Chen Zhou Z Mondal Abhisek A Abderemane-Ali Fayal F Jang Seil S Niranjan Sangeeta S Montaño José L JL Zaro Balyn W BW Minor Daniel L DL
Nature 20230517 7969
Voltage-gated ion channels (VGICs) comprise multiple structural units, the assembly of which is required for function<sup>1,2</sup>. Structural understanding of how VGIC subunits assemble and whether chaperone proteins are required is lacking. High-voltage-activated calcium channels (Ca<sub>V</sub>s)<sup>3,4</sup> are paradigmatic multisubunit VGICs whose function and trafficking are powerfully shaped by interactions between pore-forming Ca<sub>V</sub>1 or Ca<sub>V</sub>2 Ca<sub>V</sub>α<sub>1</ ...[more]
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