Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Mus Musculus (ncbitaxon:10090)
SUBMITTER: Ying Zhu
PROVIDER: MSV000090828 | MassIVE | Fri Dec 02 22:43:00 GMT 2022
REPOSITORIES: MassIVE
Fulcher James M JM Markillie Lye Meng LM Mitchell Hugh D HD Williams Sarah M SM Engbrecht Kristin M KM Degnan David J DJ Bramer Lisa M LM Moore Ronald J RJ Chrisler William B WB Cantlon-Bruce Joshua J Bagnoli Johannes W JW Qian Wei-Jun WJ Seth Anjali A Paša-Tolić Ljiljana L Zhu Ying Y
Nature communications 20241205 1
Single-cell multiomics provides comprehensive insights into gene regulatory networks, cellular diversity, and temporal dynamics. Here, we introduce nanoSPLITS (nanodroplet SPlitting for Linked-multimodal Investigations of Trace Samples), an integrated platform that enables global profiling of the transcriptome and proteome from same single cells via RNA sequencing and mass spectrometry-based proteomics, respectively. Benchmarking of nanoSPLITS demonstrates high measurement precision with deep pr ...[more]