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Changes in muscle size rewires glucose metabolism in mice

ABSTRACT: Research, especially on cancer, shows that growing cells reprogram their metabolism and synthesise lactate even in the presence of oxygen. This phenomenon has been termed the Warburg effect, and one of its key functions is to generate glycolytic intermediates for anabolic reactions to support the generation of biomass. We hypothesise that the metabolic remodelling might also be apparent during skeletal muscle hypertrophy.

INSTRUMENT(S): TripleTOF 6600

ORGANISM(S): Mus Sp. (ncbitaxon:10095)

SUBMITTER: Philipp Baumert

PROVIDER: MSV000090865 | MassIVE | Thu Dec 08 00:44:00 GMT 2022

REPOSITORIES: MassIVE

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Skeletal muscle hypertrophy rewires glucose metabolism: An experimental investigation and systematic review.

Baumert Philipp P Mäntyselkä Sakari S Schönfelder Martin M Heiber Marie M Jacobs Mika Jos MJ Swaminathan Anandini A Minderis Petras P Dirmontas Mantas M Kleigrewe Karin K Meng Chen C Gigl Michael M Ahmetov Ildus I II Venckunas Tomas T Degens Hans H Ratkevicius Aivaras A Hulmi Juha J JJ Wackerhage Henning H

Journal of cachexia, sarcopenia and muscle 20240514 3

<h4>Background</h4>Proliferating cancer cells shift their metabolism towards glycolysis, even in the presence of oxygen, to especially generate glycolytic intermediates as substrates for anabolic reactions. We hypothesize that a similar metabolic remodelling occurs during skeletal muscle hypertrophy.<h4>Methods</h4>We used mass spectrometry in hypertrophying C2C12 myotubes in vitro and plantaris mouse muscle in vivo and assessed metabolomic changes and the incorporation of the [U-<sup>13</sup>C< ...[more]

PMID: 38742477

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