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Fungal secondary metabolism is governed by an RNA-binding protein CsdA/RsdA complex, A eukaryotic functionally conserved RNA-binding protein CsdA with a global regulator RsdA coordinates fungal secondary metabolism

ABSTRACT: Production of secondary metabolites is controlled by a complicated regulatory network in eukaryotic cells. Several layers of regulators are involved in this process, ranging from pathway-specific regulation, to epigenetic control, to global regulation. A eukaryotic functionally conserved RNA-binding protein CsdA with a global regulator RsdA coordinates fungal secondary metabolism. Employing a genetic deletion approach and transcriptome analysis as well as metabolomics analysis, we revealed that CsdA and RsdA synergistically regulate fungal secondary metabolism globally.

INSTRUMENT(S): LC-MS

ORGANISM(S): Fungi (ncbitaxon:4751)

SUBMITTER: zili song

PROVIDER: MSV000091220 | MassIVE | Wed Feb 08 03:04:00 GMT 2023

REPOSITORIES: MassIVE

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Fungal secondary metabolism is governed by an RNA-binding protein CsdA/RsdA complex, A eukaryotic functionally conserved RNA-binding protein CsdA with a global regulator RsdA coordinates fungal secondary metabolism

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