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Human Cardiac Proteome of Hypertrophic Cardiomyopathy

ABSTRACT: This study utilized TMT to characterize the cardiac proteomic differences between patients with hypertrophic cardiomyopathy and controls.

INSTRUMENT(S): QExactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Dr. Michael Ackerman

PROVIDER: MSV000091821 | MassIVE | Fri Apr 28 22:21:00 BST 2023

REPOSITORIES: MassIVE

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Multi-Omic Architecture of Obstructive Hypertrophic Cardiomyopathy.

Garmany Ramin R Bos J Martijn JM Tester David J DJ Giudicessi John R JR Dos Remedios Cristobal G CG Dasari Surendra S Nagaraj Nagaswaroop K NK Nair Asha A AA Johnson Kenneth L KL Ryan Zachary C ZC Maleszewski Joseph J JJ Ommen Steve R SR Dearani Joseph A JA Ackerman Michael J MJ

Circulation. Genomic and precision medicine 20230220 2

<h4>Background</h4>Hypertrophic cardiomyopathy (HCM) is characterized by asymmetric left ventricular hypertrophy. Currently, hypertrophy pathways responsible for HCM have not been fully elucidated. Their identification could serve as a nidus for the generation of novel therapeutics aimed at halting disease development or progression. Herein, we performed a comprehensive multi-omic characterization of hypertrophy pathways in HCM.<h4>Methods</h4>Flash-frozen cardiac tissues were collected from gen ...[more]

PMID: 36802768

Publication: 1/2

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Human hypertrophic cardiomyopathy cardiac tissue phosphoproteomics

Project description:This study used TMT-pro method to look for phosphoproteomic differences in heart tissue of patients with hypertrophic cardiomyopathy and controls

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Sexual Dimorphism in Cardiac Transcriptome Associated with a Troponin C Murine Model of Hypertrophic Cardiomyopathy

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