Extracellular matrix orchestration of tissue remodelling during chronic colitis

ABSTRACT: Ulcerative colitis is a debilitating and recurrent condition with significant co-morbidities including risk of developing cancer and that is associated with extensive tissue remodeling that is both a consequence and mediator of disease progression. Here, label-free mass spectrometry was used to characterise extracellular matrix remodelling in a murine model of colitis. Unique proteomic profiles of the extracellular matrix landscape distinguished inflamed from matched-normal colon tissue thus identifying pre- and pathological colitic states that were predominantly differentiated by expression of proteoglycans. Network maps derived from this dataset highlighted a central role for matrisomal proteins in epithelial-stromal interactions and identified orchestrating nodes that could be exploited in selection of therapeutic targets.

INSTRUMENT(S): Orbitrap Eclipse

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Birgit Schilling  

PROVIDER: MSV000092056 | MassIVE | Tue May 30 16:06:00 BST 2023

SECONDARY ACCESSION(S): PXD042551

REPOSITORIES: MassIVE