Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF Pro 2
ORGANISM(S): Mus Musculus (ncbitaxon:10090)
SUBMITTER: Isha Jain
PROVIDER: MSV000092095 | MassIVE | Sun Jun 04 09:38:00 BST 2023
SECONDARY ACCESSION(S): PXD042712
REPOSITORIES: MassIVE
Chen Xuewen X Haribowo Augustinus G AG Baik Alan H AH Fossati Andrea A Stevenson Erica E Chen Yiwen R YR Reyes Nabora S NS Peng Tien T Matthay Michael A MA Traglia Michela M Pico Alexander R AR Jarosz Daniel F DF Buchwalter Abigail A Ghaemmaghami Sina S Swaney Danielle L DL Jain Isha H IH
Science advances 20231208 49
Oxygen deprivation and excess are both toxic. Thus, the body's ability to adapt to varying oxygen tensions is critical for survival. While the hypoxia transcriptional response has been well studied, the post-translational effects of oxygen have been underexplored. In this study, we systematically investigate protein turnover rates in mouse heart, lung, and brain under different inhaled oxygen tensions. We find that the lung proteome is the most responsive to varying oxygen tensions. In particula ...[more]