Dataset Information
A general multipronged activation approach for natural product discovery in Actinomycetes 54 actinobacterial strains with genetic and cultivation based activation
Ontology highlight
ABSTRACT:
INSTRUMENT(S): 6540 Q-TOF LC/MS
ORGANISM(S): Streptomyces Viridochromogenes (ncbitaxon:1938) Streptomyces Abikoensis (ncbitaxon:97398) Thermoactinomyces Vulgaris (ncbitaxon:2026) Streptomyces Albogriseolus (ncbitaxon:1887) Streptomyces Sampsonii (ncbitaxon:42239) Streptomyces Ardesiacus Streptomyces Fradiae (ncbitaxon:1906) Streptomyces Filipinensis (ncbitaxon:66887) Streptomyces Niveiscabiei (ncbitaxon:164115) Streptomyces Odonnellii (ncbitaxon:1417980) Streptomyces Anandii (ncbitaxon:285454) Streptomyces Thermocarboxydus (ncbitaxon:59299) Streptomyces Flaveolus (ncbitaxon:67297) Streptomyces Albofaciens (ncbitaxon:66866) Micromonospora Maris Streptomyces Luridiscabiei (ncbitaxon:164114) Streptomyces Lavendulae (ncbitaxon:1914) Streptomyces (ncbitaxon:1883) Spirillospora Tritici Streptomyces Kronopolitis (ncbitaxon:1612435) Streptomyces Niveoruber (ncbitaxon:68243) Streptomyces Cyaneochromogenes Streptomyces Lunaelactis (ncbitaxon:1535768) Streptomyces Hirsutus (ncbitaxon:35620) Streptomyces Jeddahensis (ncbitaxon:1716141) Streptomyces Tendae Strain Atcc 19812 Micromonospora Oryzae (ncbitaxon:1530046) Streptomyces Nigrescens (ncbitaxon:1920) Streptomyces Durhamensis (ncbitaxon:68194) Streptomyces Variabilis (ncbitaxon:67372) Micromonospora Aurantiaca (ncbitaxon:47850) Streptomyces Tendae (ncbitaxon:1932) Micromonospora Maritima (ncbitaxon:986711) Streptomyces Globisporus (ncbitaxon:1908) Dactylosporangium Solaniradicis (ncbitaxon:1758122)
SUBMITTER: 
Fong Tian Wong
PROVIDER: MSV000092237 | MassIVE | Thu Jun 22 00:30:00 BST 2023
REPOSITORIES: MassIVE
Publications
Exploring a general multi-pronged activation strategy for natural product discovery in Actinomycetes.
Communications biology 20240106 1
Natural products possess significant therapeutic potential but remain underutilized despite advances in genomics and bioinformatics. While there are approaches to activate and upregulate natural product biosynthesis in both native and heterologous microbial strains, a comprehensive strategy to elicit production of natural products as well as a generalizable and efficient method to interrogate diverse native strains collection, remains lacking. Here, we explore a flexible and robust integrase-med ...[more]
