Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

ABSTRACT: The accumulation of amyloid beta peptides in fibrils is prerequisite for Alzheimers disease (AD). Our understanding of the proteins that promote Abeta fibril formation and mediate neurotoxicity has been limited due to technical challenges in isolating pure amyloid fibrils from brain extracts.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116)

SUBMITTER: Jeffrey N. Savas, PhD  

PROVIDER: MSV000092311 | MassIVE | Thu Jun 29 14:50:00 BST 2023

SECONDARY ACCESSION(S): PXD043408

REPOSITORIES: MassIVE