Nix Interacts with WIPI2 to Induce Mitophagy
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: 
Yan Wang
PROVIDER: MSV000092324 | MassIVE | Fri Jun 30 15:01:00 BST 2023
SECONDARY ACCESSION(S): PXD043441
REPOSITORIES: MassIVE
Publications
Nix interacts with WIPI2 to induce mitophagy.
Bunker Eric N EN Le Guerroué François F Wang Chunxin C Strub Marie-Paule MP Werner Achim A Tjandra Nico N Youle Richard J RJ
The EMBO journal 20230825 22
Nix is a membrane-anchored outer mitochondrial protein that induces mitophagy. While Nix has an LC3-interacting (LIR) motif that binds to ATG8 proteins, it also contains a minimal essential region (MER) that induces mitophagy through an unknown mechanism. We used chemically induced dimerization (CID) to probe the mechanism of Nix-mediated mitophagy and found that both the LIR and MER are required for robust mitophagy. We find that the Nix MER interacts with the autophagy effector WIPI2 and recru ...[more]
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