Proteomics

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Top-down Proteomics of 10,000 Single Brain Cells


ABSTRACT: We perform intact proteoform profiling of 10809 endogenous single cells from the rat hippocampus using single-cell Proteoform imaging Mass Spectrometry (scPiMS). scPiMS directly extracts whole proteins and demonstrates high throughput for mass spectrometry-based single cell proteomics compared to existing approaches. We develop an informatics workflow dedicated to this datatype and use it to assign neurons, astrocytes or microglia cell types according to their proteoform signatures.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116)

SUBMITTER: Neil L Kelleher  

PROVIDER: MSV000092360 | MassIVE | Thu Jul 06 13:08:00 BST 2023

REPOSITORIES: MassIVE

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