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Loss of function cancer associated mutations in the EIF4G2 non canonical translation initiation factor

ABSTRACT: Tumor cells often exploit the protein translation machinery, resulting in enhanced protein expression essential for tumor growth. Since canonical translation initiation is often suppressed due to cell stress in the tumor microenvironment, non-canonical translation initiation mechanisms become particularly important for shaping the tumor proteome. EIF4G2 is a non-canonical translation initiation factor that mediates internal ribosome entry site (IRES) and upstream open reading frame (uORF) dependent initiation mechanisms, which can be used to modulate protein expression in cancer. Here we explored the contribution of EIF4G2 to cancer by screening the COSMIC database for EIF4G2 somatic mutations in cancer patients.

INSTRUMENT(S): timsTOF Pro, Q Exactive HF-X

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Adi Kimchi

PROVIDER: MSV000092704 | MassIVE | Mon Aug 21 01:06:00 BST 2023

SECONDARY ACCESSION(S): PXD044678

REPOSITORIES: MassIVE

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