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Sexual Dimorphism in the Extracellular and Pericellular Matrix of Articular Cartilage

ABSTRACT: Male and female collagen-enriched fraction of cartilage from bovine knees. Full thickness cartilage plugs without subchondral bone were digested with chondroitinase for 24 hours to remove proteoglycans. Cartilage was further decellularized with SDS. LUM1_811145: channels 126, 127, 128 female, channels 129, 130, 131 male LUM1_833734: channels 126, 127, 128 female, channels 129, 130, 131 male

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Bos Taurus (ncbitaxon:9913)

SUBMITTER: Paula A. Hernandez

PROVIDER: MSV000092997 | MassIVE |

REPOSITORIES: MassIVE

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Sexual Dimorphism in the Extracellular and Pericellular Matrix of Articular Cartilage.

Hernandez Paula A PA Moreno Miranda M Barati Zahra Z Hutcherson Conner C Sathe Adwait A AA Xing Chao C Wright Jamie J Welch Tre T Dhaher Yasin Y

Cartilage 20220701 3

<h4>Objective</h4>Women have a higher prevalence and burden of joint injuries and pathologies involving articular cartilage than men. Although knee injuries affecting young women are on the rise, most studies related to sexual dimorphism target postmenopausal women. We hypothesize that sexual dimorphism in cartilage structure and mechanics is present before menopause, which can contribute to sex disparities in cartilage pathologies.<h4>Design</h4>Bovine knee was used as a model to study healthy ...[more]

PMID: 36069595

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