Dataset Information
ROS transfer at peroxisome-mitochondria contact sites maintains mitochondrial redox homeostasis
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: 
Brian Raught
PROVIDER: MSV000093219 | MassIVE | Wed Nov 01 06:49:00 GMT 2023
SECONDARY ACCESSION(S): PXD046577
REPOSITORIES: MassIVE
Publications
ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox.
Science (New York, N.Y.) 20250710 6756
Maintenance of mitochondrial redox homeostasis is of fundamental importance to cellular health. Mitochondria harbor a host of intrinsic antioxidant defenses, but the contribution of extrinsic, nonmitochondrial antioxidant mechanisms is less well understood. We found a direct role for peroxisomes in maintaining mitochondrial redox homeostasis through contact-mediated reactive oxygen species (ROS) transfer. We found that ACBD5 and PTPIP51 form a contact between peroxisomes and mitochondria. The pe ...[more]
