Dataset Information

Itaconate modulates immune responses via inhibition of peroxiredoxin 5

ABSTRACT: Wild type and Irg1 knockout mouse bone marrow derived macrophages (BMDMs) were processed with a redox proteomics workflow and analyzed by LC-MS/MS with TMT based quantification.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Wei-Jun Qian

PROVIDER: MSV000093232 | MassIVE | Wed Nov 01 16:52:00 GMT 2023

SECONDARY ACCESSION(S): PXD046597

REPOSITORIES: MassIVE

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Itaconate modulates immune responses via inhibition of peroxiredoxin 5.

Paulenda Tomas T Echalar Barbora B Potuckova Lucie L Vachova Veronika V Kleverov Denis A DA Mehringer Johannes J Potekhina Ekaterina E Jacoby Alex A Sen Devashish D Nelson Chris C Stegeman Rick R Sukhov Vladimir V Kemper Danielle D Lichti Cheryl F CF Day Nicholas J NJ Zhang Tong T Husarcikova Kamila K Bambouskova Monika M Fremont Daved H DH Qian Wei-Jun WJ Djuranovic Sergej S Pavlovic-Djuranovic Slavica S Belousov Vsevolod V VV Krezel Andrzej M AM Artyomov Maxim N MN

Nature metabolism 20250418

The immunoregulatory metabolite itaconate accumulates in innate immune cells upon Toll-like receptor stimulation. In response to macrophage activation by lipopolysaccharide, itaconate inhibits inflammasome activation and boosts type I interferon signalling; however, the molecular mechanism of this immunoregulation remains unclear. Here, we show that the enhancement of type I interferon secretion by itaconate depends on the inhibition of peroxiredoxin 5 and on mitochondrial reactive oxygen specie ...[more]

PMID: 40251412

Dataset Information

Itaconate modulates immune responses via inhibition of peroxiredoxin 5

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Publications

Itaconate modulates immune responses via inhibition of peroxiredoxin 5.

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