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TARGETING NEURONAL FTL1 RESCUES COGNTIVE IMPAIRMENTS IN AGING

ABSTRACT: Raw files of protein abundance from TMT-labeled mouse cortical and hippocampal synaptosomes analyzed on an Orbitrap Fusion Lumos

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Saul A. Villeda

PROVIDER: MSV000093450 | MassIVE | Tue Nov 21 11:18:00 GMT 2023

REPOSITORIES: MassIVE

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Publications

Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment.

Remesal Laura L Sucharov-Costa Juliana J Wu Yuting Y Pratt Karishma J B KJB Bieri Gregor G Philp Amber A Philp Amber A Phan Mason M Aghayev Turan T White Charles W CW Wheatley Elizabeth G EG Zou Bende B Desousa Brandon R BR Couthouis Julien J Jian Isha H IH Xie Xinmin S XS Lu Yi Y Maynard Jason C JC Burlingame Alma L AL Villeda Saul A SA

Nature aging 20250819 10

Understanding cellular and molecular drivers of age-related cognitive decline is necessary to identify targets to restore cognition at old age. Here we identify ferritin light chain 1 (FTL1), an iron-associated protein, as a pro-aging neuronal factor that impairs cognition. Using transcriptomic and mass spectrometry approaches, we detect an increase in neuronal FTL1 in the hippocampus of aged mice, the levels of which correlate with cognitive decline. Mimicking an age-related increase in neurona ...[more]

PMID: 40830655

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