Proteomics

Dataset Information

0

Active site remodeling of IDH1 by tumor_relevant mutations and potential resistance mechanisms

ABSTRACT: HDXMS data on isocitrate dehydrogenase (IDH1) and variants of the enzyme bound to cofactors and substrates.

INSTRUMENT(S): Synapt G2 HDMS

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Christal Sohl  

PROVIDER: MSV000094158 | MassIVE | Sat Feb 24 18:58:00 GMT 2024

SECONDARY ACCESSION(S): PXD050109

REPOSITORIES: MassIVE

Json Xml

Similar Datasets

Unknown Active site remodeling switches HIV specificity of antiretroviral TRIMCyp.
| S-EPMC3556581 | biostudies-literature
Unknown Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14α-demethylase.
| S-EPMC4870556 | biostudies-literature
Unknown Target-Site Mutations Conferring Herbicide Resistance.
| S-EPMC6843678 | biostudies-literature
Unknown Biochemical analysis of active site mutations of human polymerase ?.
| S-EPMC3669660 | biostudies-literature
Unknown Active site mutations change the cleavage specificity of neprilysin.
| S-EPMC3285688 | biostudies-literature
Unknown Evolution of a designed retro-aldolase leads to complete active site remodeling.
| S-EPMC3720730 | biostudies-literature
Unknown Structural studies on molecular mechanisms of Nelfinavir resistance caused by non-active site mutation V77I in HIV-1 protease.
| S-EPMC4686784 | biostudies-literature
Unknown Sulfide-binding hemoglobins: Effects of mutations on active-site flexibility.
| S-EPMC1544295 | biostudies-literature
Unknown Domain alternation and active site remodeling are conserved structural features of ubiquitin E1.
| S-EPMC5519361 | biostudies-literature
Other Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact
2020-08-10 | GSE149922 | GEO