Serum proteome in metastatic breast cancer patients

ABSTRACT: We identified 967 proteins among 75 serum samples from patients with BC. Among these, 39 proteins were altered in serum samples at diagnosis, between progressors and non-progressors. Among these, 4 proteins were further altered when the progressors developed distant metastasis. In addition, within progressors, 20 proteins were altered in serum collected at diagnosis versus at the onset of metastasis. Pathway analysis showed that these proteins encoded pathways that describe metastasis, including epithelial mesenchymal transition and focal adhesion that are hallmarks of metastatic cascade.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Sung Yun Jung  

PROVIDER: MSV000094255 | MassIVE | Thu Mar 07 09:28:00 GMT 2024

SECONDARY ACCESSION(S): PXD050451

REPOSITORIES: MassIVE