Dataset Information
Proteomic profile of hippocampus regions from the pilocarpine medial temporal lobe epilepsy model
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116)
SUBMITTER: 
Iscia Lopes Cendes
PROVIDER: MSV000094401 | MassIVE | Mon Mar 25 10:59:00 GMT 2024
SECONDARY ACCESSION(S): PXD050962
REPOSITORIES: MassIVE
Publications
Multi-omics analysis suggests enhanced epileptogenesis in the Cornu Ammonis 3 of the pilocarpine model of mesial temporal lobe epilepsy.
Hippocampus 20201010 2
Mesial temporal lobe epilepsy (MTLE) is a chronic neurological disorder characterized by the occurrence of seizures, and histopathological abnormalities in the mesial temporal lobe structures, mainly hippocampal sclerosis (HS). We used a multi-omics approach to determine the profile of transcript and protein expression in the dorsal and ventral hippocampal dentate gyrus (DG) and Cornu Ammonis 3 (CA3) in an animal model of MTLE induced by pilocarpine. We performed label-free proteomics and RNAseq ...[more]
