Comparison of the Amyloid Plaque Proteome in Down Syndrome and Alzheimers Disease

ABSTRACT: Using unbiased localized proteomics, we analyzed amyloid plaques and adjacent plaque-devoid tissue (non-plaque) from post-mortem paraffin-embedded tissues in three cohorts (n=20/group): Down Syndrome, Early Onset AD, and Late Onset AD. We assessed functional associations using Gene Ontology (GO) enrichment and protein interaction networks

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Beatrix Ueberheide  

PROVIDER: MSV000094800 | MassIVE | Sat May 18 14:09:00 BST 2024

REPOSITORIES: MassIVE