Human IgG subclasses differ in structural elements of their N-glycosylation

ABSTRACT: We tested tryptic plasma samples using HILIC-LC-MS/MS, which included mixed human plasma as well as plasma from two healthy individuals collected at three different time points, approximately one month apart. Our focus was on the glycan structure of the Fc domain of IGG subclasses. The results indicated that each IGG subclass possesses a distinct glycan signature. Although there were slight variations between individuals, the glycan signature of IGG subclasses in individual plasma remained stable over time.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Karli Reiding  

PROVIDER: MSV000095017 | MassIVE | Thu Jun 13 01:59:00 BST 2024

REPOSITORIES: MassIVE