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DNA O-MAP uncovers the molecular neighborhoods associated with specific genomic loci

ABSTRACT: Here, we introduce a method termed DNA O-MAP, which uses programmable peroxidase-conjugated oligonucleotide probes to biotinylate nearby proteins. We show that DNA O-MAP can be coupled with sample multiplexed quantitative proteomics and next-generation sequencing to quantify DNA-protein and DNA-DNA interactions at specific genomic loci.

INSTRUMENT(S): Orbitrap Eclipse

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Devin Schweppe

PROVIDER: MSV000095396 | MassIVE | Sat Jul 20 14:19:00 BST 2024

SECONDARY ACCESSION(S): PXD054080

REPOSITORIES: MassIVE

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