Dataset Information

Apolipoprotein A-II Increases Cholesterol Efflux Capacity of Mature High-Density Lipoproteins Via the Apolipoprotein A-I C-terminus

ABSTRACT: Samples were processed using Global and Limited Proteolysis (LiP). Peptides and proteins were identified using MaxQuant (v1.6.17.0), then summarized using R package RomicsProcessor.

INSTRUMENT(S): Orbitrap Fusion Lumos, Q Exactive HF-X

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: John T. Melchior

PROVIDER: MSV000095479 | MassIVE | Mon Jul 29 16:56:00 BST 2024

REPOSITORIES: MassIVE

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APOA2 increases cholesterol efflux capacity to plasma HDL by displacing the C-terminus of resident APOA1.

Sarkar Snigdha S Morris Jamie J You Youngki Y Sexmith Hannah H Street Scott E SE Thibert Stephanie M SM Attah Isaac K IK Hutchinson Bunch Chelsea M CM Novikova Irina V IV Evans James E JE Shah Amy S AS Gordon Scott M SM Segrest Jere P JP Bornfeldt Karin E KE Vaisar Tomas T Heinecke Jay W JW Davidson W Sean WS Melchior John T JT

Journal of lipid research 20241028 12

The ability of high-density lipoprotein (HDL) to promote cellular cholesterol efflux is a more robust predictor of cardiovascular disease protection than HDL-cholesterol levels in plasma. Previously, we found that lipidated HDL containing both apolipoprotein A-I (APOA1) and A-II (APOA2) promotes cholesterol efflux via the ATP-binding cassette transporter (ABCA1). In the current study, we directly added purified, lipid-free APOA2 to human plasma and found a dose-dependent increase in whole plasma ...[more]

PMID: 39490930

Dataset Information

Apolipoprotein A-II Increases Cholesterol Efflux Capacity of Mature High-Density Lipoproteins Via the Apolipoprotein A-I C-terminus

Dataset's files

Publications

APOA2 increases cholesterol efflux capacity to plasma HDL by displacing the C-terminus of resident APOA1.

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