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Effects of Navitoclax and Venetoclax on changes in the proteome of mouse pancreas in a mouse model of chronic pancreatitis

ABSTRACT: Effects of two Bcl-2 protein inhibitors Navitoclax and Venetoclax on changes in the proteome of the mouse pancreas (Mus musculus C57BL6/J, males) in a mouse model of cerulein-induced chronic pancreatitis.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Pawel Ferdek

PROVIDER: MSV000095776 | MassIVE |

SECONDARY ACCESSION(S): PXD055578

REPOSITORIES: MassIVE

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Publications

Repurposing BCL2 inhibitors: Venetoclax protects against acinar cell necrosis in acute pancreatitis by promoting apoptosis.

Litewka Jacek J JJ Szopa Mateusz D MD Fryt Katarzyna K Jakubowska Monika A MA Jankowska Urszula U Skupien-Rabian Bozena B Hajduk Karolina K Werner Ewa E Stopa Kinga B KB Kusiak Agnieszka A AA Krzysztofik Daria D Madeja Zbigniew Z Ferdek Pawel E PE

Cell death & disease 20250727 1

Acute pancreatitis (AP), a severe inflammatory disorder of the pancreas, lacks effective pharmacological treatment. The disease is primarily driven by necrosis of pancreatic acinar cells (PACs), which intensifies inflammation and organ injury. This study explores the potential of BCL2 inhibitors, specifically Navitoclax and Venetoclax, to shift cell death pathways from necrosis to apoptosis and thereby mitigate disease severity. Ex vivo models using cerulein or ethanol/palmitoleic acid (EtOH/POA ...[more]

PMID: 40715042

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